Endocrine Abstracts

Introduction: Ovariectomized C57BL/6 mice are a good model to study the postmenopausal stage. It has been reported that high-fat diet (HFD) augments the body fat mass and insulin resistance (IR) in animal models. Goal of this study was to investigate the combined effects of ovariectomy (OVX) and HFD on insulin sensitivity and pancreatic remodeling in C57BL/6 mice treated with bezafibrate.Methods: Female C57BL/6 mice were subjected to surgical OVX and sur...